Enriching leukapheresis improves T cell activation and transduction efficiency during CAR T processing
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منابع مشابه
B and T Lymphocyte Attenuator is a Target of miR-155 during Naive CD4+ T Cell Activation
Background: MicroRNA-155 (miR-155) is upregulated during T cell activation, but the exact mechanisms by which it influences CD4+ T cell activation remain unclear. Objective: To examine whether the B and T lymphocyte attenuator (BTLA) is a target of miR-155 during naïve CD4+ T cell activation. Methods: Firefly luciferase reporter plasmids pEZX-MT01-wild-type-BTLA and pEZX-MT01-mutant-BTLA were ...
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For initiation of an immune response, resting T cells must reprogram their metabolism. Continuing the "From the Field" series (see Editorial [2007] 26, 131), Jones and Thompson draw attention to the importance of metabolism during T cell activation and consider how this process is regulated by receptor-mediated signal transduction.
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CD28 co-receptor signal transduction in T-cell activation P. J. Blair*, J. L. Riley-tS, R. G. Carrollt, D. C. St. Louist, B. L. Levine*, B. Saha*, K. P. Lee*, P. 1. Perrin*, D. M. Harlan* and C. H. June*§ *Immune Cell Biology Program, Naval Medical Research Institute, I809 Wisconsin Ave., Bethesda, MD 208 14-5607, tHenry M. Jackson Foundation for the Advancement of Military Medicine, Rockville,...
متن کاملb and t lymphocyte attenuator is a target of mir-155 during naive cd4+ t cell activation
background: microrna-155 (mir-155) is upregulated during t cell activation, but the exact mechanisms by which it influences cd4+ t cell activation remain unclear. objective: to examine whether the b and t lymphocyte attenuator (btla) is a target of mir-155 during naïve cd4+ t cell activation. methods: firefly luciferase reporter plasmids pezx-mt01-wild-type-btla and pezx-mt01-mutant-btla were c...
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ژورنال
عنوان ژورنال: Molecular Therapy - Methods & Clinical Development
سال: 2021
ISSN: 2329-0501
DOI: 10.1016/j.omtm.2021.02.002